We shows the maternal behavior deficits in female olfactory bulbectomy (OBX) mice, and these deficits were ameliorated by administration of apomorphine. These results suggest that maternal behavior deficits in OBX dams may involve brain hypodopaminergic function in the central nervous system induced by OBX. (うつ病の動物モデルの母性行動が障害され、またその母性行動がドパミン受容体作用薬で改善することから、うつ病の動物モデルの母性行動障害には脳内ドパミン神経系の関与が示唆された。)
pp.251-256
Atsushi Sato, Osamu Nakagawasai, Koichi Tan-No, Hiroshi Onogi, Takeshi Tadano, et al.