It was examined the effects of angiotensin-converting enzyme inhibitor, exercise training and their combination on exercise capacity as well as skeletal muscle fiber type and capillarity in spontaneously hypertensive rats (SHR).We found that in growing SHR, chronic treatment with perindopril enhances untrained exercise capacity.We also found that perindopril promotes adaptive changes of skeletal muscle in response to exercise.
pp.1241-1248
Minami N, Li Y, Guo Q, Kawamura T, Kohzuki M